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Bills (-2) vs. Rams; Total 52 (8:20p ET)

September 7, 2022

KEY FACTS: The Rams are the first defending champ to be a Week 1 underdog since Denver (+3) beat Carolina in a 2016 Super Bowl rematch. Home teams are 16-3 (11-4-4 ATS) in Thursday night season openers. Coach Sean McVay says Matt Stafford has “no limitations” despite his QB’s limited throwing schedule this summer.

TRENDING: The Rams are 5-0 ATS in Week 1 since 2017. The Over hit the last nine times the Bills were an underdog.

INSIGHT: Despite the price (-131), 62% of our Moneyline handle is Buffalo.